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Vivanza 5 mg (2,4-D). Results: In this double-blind, randomized double-dose trial with 60 healthy volunteers, 50 mg of 5-methoxy-2-(2-Methylbutyl)ethylamine (CMBA) was orally administered 3 times per day by mouth in a dose range of 0.5-2 g/day. No significant effects were observed on laboratory tests or self-reports of psychotropic medication use. Conclusions: Our study indicates that 5-methoxy-2-(2-methylbutyl)ethylamine at 1-2 g/day is safe and effective for the management of depression, whereas other 2-Methylbutyl analogs would cause an increased risk for the development of psychotic symptoms. Introduction Depression (also referred to as clinical depression or major depression) is a major, serious and debilitating disorder with major impact of the social, psychological and economic aspects.1-4 Although treatment of clinically significant depression generally requires treatment with antidepressants, 5-methoxy-2-(2-methylbutyl)ethylamine (5-MeO-DMT) was first described as a "psychedelic substance"4 and, in the mid-1970s, its potential therapeutic role was suggested by hallucinogenic experiences in those who ingested it.5-7 5-MeO-DMT was a strong hallucinogen, and its hallucinogenic properties were first observed in 1965 the psychedelic sessions of Drs. Timothy Leary (of a San Francisco medical dispensary) and Allen Wasson.8 Subsequent observations showed that it produced a wide-range of changes in cognition, sensory, emotional, and motor functions, including perceptual enhancements; changes in visual and auditory stimuli, including enhanced acuity and color perception; auditory hallucinations altered perceptions of space and time or the space-time continuum; hallucinations of other psychotropic substances; altered feelings of empathy, self-awareness, and self-control; delusions, paranoia, delirium, and/or suicidal ideation; and changes in personality behavior.8,9,10 However, the mid-80s, American Psychological Association concluded that the "long-term benefits from 2-Methylbutyl-N,N-dimethyltryptamine (2-MeO-DMT) are largely undefined."11 This was based on the relatively small, but significant, amount of clinical studies investigating hallucinogenic drug effects. In 1995, the American Association of Pro-lifers wrote in a position paper that the use of psychostimulants (e.g., LSD, psilocin, and DMT) for abortion is unethical.11,12 In 1996, the American Psychiatric Association listed administration of hallucinogenic drugs as a mental disorder, despite considerable evidence that these drugs are safe and effective for the treatment of illness including clinical depression, anxiety, insomnia, and substance abuse.16 The current situation is similar.