Another disadvantage of non-infectious vaccines is that the protection they confer generally is not as long-lasting as the protection produced by vaccination with a live microbe.
Lauren Sompayrac, Ph.D., How the Immune System Works, 6th Edition, (2019) Wiley, Blackwell, Hoboken, NJ, p 127
In order for a vaccine to mimic the invasion of a pathogenic microbe, the immune system must view the vaccine as both foreign and dangerous. This is not a problem for a vaccine which uses a crippled virus — because a crippled virus naturally provides both signals. However, for vaccines composed of only one or a few microbial proteins, providing the requisite danger signal can be a serious problem. Indeed, if a foreign protein is injected into a human, the immune system generally just ignores it — because it poses no danger. (EMPHASIS ADDED)
Because of the requirement for a danger signal, it is common practice to combine vaccines with an adjuvant (derived from a Latin word meaning “help”). In fact most of the vaccinations that you have received probably contained aluminum hydroxide or “alum,” which functions, at least in part, by providing that important danger signal.
Lauren Sompayrac, Ph.D., How the Immune System Works, 6th Edition, (2019) Wiley, Blackwell, Hoboken, NJ, p 130
What danger signal means is that the “adjuvants” are toxins that activate the immune system.
The mRNA based COVID vaccines from Moderna and Pfizer/BIONTech are non-infectious vaccines, also known as inactivated vaccines, largely comprised of the SARS-COV-2 spike protein manufactured from the mRNA which purportedly codes for the spike protein. The spike protein binds to the ACE-2 receptor, the angiotensin converting enzyme II receptor, and enables the SARS-COV-2 virus to enter the cells by imitating angiotensin. Angiotensin is a key component of a complex system that regulates blood pressure and cardiovascular function.
The main point is one would always have expected the COVID vaccines based on past experience with non-infectious — also known as inactivated vaccines — to fade and require boosters at some point, unlike live attenuated vaccines. This is a perpetual money machine just like selling an addictive pain killer such as oxycontin to patients or a deadly non-addictive short term pain killer that wears off and requires repeat uses and repeat purchases — like Vioxx — to patients. We now know the COVID vaccines fade in a matter of months if they work at all.
(C) 2022 by John F. McGowan, Ph.D.
About Me
John F. McGowan, Ph.D. solves problems using mathematics and mathematical software, including developing gesture recognition for touch devices, video compression and speech recognition technologies. He has extensive experience developing software in C, C++, MATLAB, Python, Visual Basic and many other programming languages. He has been a Visiting Scholar at HP Labs developing computer vision algorithms and software for mobile devices. He has worked as a contractor at NASA Ames Research Center involved in the research and development of image and video processing algorithms and technology. He has published articles on the origin and evolution of life, the exploration of Mars (anticipating the discovery of methane on Mars), and cheap access to space. He has a Ph.D. in physics from the University of Illinois at Urbana-Champaign and a B.S. in physics from the California Institute of Technology (Caltech).